Specification of transplantable astroglial subtypes from human pluripotent stem cells
نویسندگان
چکیده
منابع مشابه
Specification of Hemato-Endothelial-Like Structures and Generation of Hematopoietic Progenitor Cells from Human Pluripotent Stem Cells
Background and purpose: Human pluripotent stem cells (hPSCs) with the ability to differentiate into adult cells have provided a new perspective for treatment of some diseases. But, the efficiency of differentiation methods to generate hematopoietic progenitor cells (HPCs) is faced with multiple challenges. In the present study, we investigated the formation of hemato-endothelial-like structure...
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Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An...
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1Harvard Medical School, Boston, MA; 2Harvard Stem Cell Institute, Boston, MA; 3Department of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA; 4Department of Laboratory Medicine, Joint Program in Transfusion Medicine, Children’s Hospital, Boston, MA; 5Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; and 6Cancer Science Instit...
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Background: We have recently shown that human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) can differentiate into advanced spermatogenic cells including round spermatids by in vitro culture (Easley et al., Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Reports 2, 440-446 2012) and also, in collaboration, that rhesus spermatogonial ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2011
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.1877